pandora bracelets The cumulative incidence of rheumatoid arthritis increased with increasing rheumatoid factor category (Ptrend100 IU/mL, compared with trend100 IU/mL.Conclusion Individuals in the general population with elevated rheumatoid factor have up to 26 fold greater long term risk of rheumatoid arthritis, and up to 32% 10 year absolute risk of rheumatoid arthritis. These novel findings may lead to revision of guidelines for early referral to a rheumatologist and early arthritis clinics based on rheumatoid factor testing.IntroductionRheumatoid arthritis is an autoimmune disease affecting 0.5 2% of the population.1 2 Although modern treatments for rheumatoid arthritis can induce remission in many patients,pandora jewelry diagnosis of rheumatoid arthritis in early disease stages is important for preventing irreversible damage to the synovial lining and cartilage of diseased joints and for preventing progression into later disease stages.3 4 5 6 7 At present, there is no good clinical available indicator for long term development of rheumatoid arthritis.8 9 10Rheumatoid factor is an autoantibody targeting the Fc region of IgG antibodies.1 Testing for rheumatoid factor is the most widely used blood test in the classification of rheumatoid arthritis.3 11 In the current classification criteria for rheumatoid arthritis3 “definite rheumatoid arthritis” is based on the confirmed presence of synovitis in at least one joint, absence of an alternate diagnosis better explaining the synovitis, and achievement of a total score of 6 (of a possible 10) on a scoring system. The score is derived from four criteria: the number and site of affected joints (range 0 5), serological abnormality (elevated levels of rheumatoid factor or anti citrullinated protein antibody; range 0 3), elevated acute phase response (range 0 1), and symptom duration (v 6 weeks; range 0 1). pandora bracelets
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